Journal of Neurosciences in Rural Practice

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 10  |  Issue : 2  |  Page : 185--193

Mindbomb Homolog-1 index in the prognosis of high-grade glioma and its clinicopathological correlation


Shyam Sundar Krishnan1, Shanmugam Muthiah1, Shilpa Rao2, Suganthi Srinivasan Salem3, Vasudevan Chakravarthy Madabhushi1, Anita Mahadevan4 
1 Department of Neurosurgery, PGINS, ALNC, VHS Hospital, Chennai, Tamil Nadu, India
2 Department of Neuropathology, NIMHANS Hospital, Bengaluru, Karnataka, India
3 IIT Madras Research Park, IIT Madras, Chennai, Tamil Nadu, India
4 Department of Neuropathology, Human Brain Tissue Repository, NIMHANS, Bengaluru, Karnataka, India

Correspondence Address:
Shyam Sundar Krishnan
Post-Graduate Institute of Neurological Surgery, Dr. Achanta Lakshmipathi Neurosurgical Centre, Voluntary Health Services Multipeciality Hospital & Research Centre, Rajiv Gandhi Salai, TTTI Post, Tharamani, Adyar, Chennai - 600113, Tamil Nadu
India

Introduction: Gliomas are the most common brain tumors in adults originating from the glial cells. Glioblastoma multiforme is the most malignant and frequent among all gliomas. In recent years, the antibody Mindbomb Homolog-1 (MIB-1) has evolved as a measure of the proliferative nature of the glial tumors. This study aims to investigate the MIB-1 index value as an independent prognostic factor in high-grade gliomas and its correlation with outcome and survival. Materials and Methods: Mean MIB-1 index was determined in 51 high-grade glioma tissue samples in formalin. Its correlation with outcome by assessing the clinicoradiological parameters and median survival of patients in months were assessed. Survival analysis was studied by using the Kaplan–Meier bivariate analysis and Cox proportional ratio. Results: Preoperative Karnofsky Performance Score, WHO-PS, Neurological Performance Scale, and Mini–Mental Status Examination (MMSE) were statistically significant with respect to outcome and survival, whereas tumor factors such as size and perilesional edema were not. In particular, midline-crossing tumors and deep-seated tumors were significantly associated with high MIB-1 index and by correlation with outcome. There were significantly higher number (P < 0.0001) of patients with Grade IV tumors, with an MIB-1 index value above an arbitrary cutoff of 10% compared to Grade III tumors. In addition, median survival period of patients with low MIB-1 index was longer irrespective of tumor grade. Conclusion: Significant correlation between high-grade glioma and MIB-1 index suggests MIB-1 index to be a good prognostic tool, with MIB-1 index and midline-crossing variables being independent prognostic parameters.


How to cite this article:
Krishnan SS, Muthiah S, Rao S, Salem SS, Madabhushi VC, Mahadevan A. Mindbomb Homolog-1 index in the prognosis of high-grade glioma and its clinicopathological correlation.J Neurosci Rural Pract 2019;10:185-193


How to cite this URL:
Krishnan SS, Muthiah S, Rao S, Salem SS, Madabhushi VC, Mahadevan A. Mindbomb Homolog-1 index in the prognosis of high-grade glioma and its clinicopathological correlation. J Neurosci Rural Pract [serial online] 2019 [cited 2019 May 20 ];10:185-193
Available from: http://www.ruralneuropractice.com/article.asp?issn=0976-3147;year=2019;volume=10;issue=2;spage=185;epage=193;aulast=Krishnan;type=0