Journal of Neurosciences in Rural Practice
 
CASE SERIES
Year : 2016  |  Volume : 7  |  Issue : 3  |  Page : 435-439

Assessment of intracranial metastases from neuroendocrine tumors/carcinoma


1 Department of Oncologic Pathology, Kameda Hospital and Oncology Center, Kamogawa Chiba, Japan
2 Department of Immunology, Damanhour National Medical Institute, Damanhour, Egypt
3 Department of Pathology, KAAZ Hospital and Oncology Center, Jeddah, Saudi Arabia

Correspondence Address:
Ahmed M Ragab Shalaby
Apt. 503173, Ahmad Shawki Street, Roushdi, Alexandria
Japan
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-3147.182779

Rights and Permissions

Background: The most common sites of origin for neuroendocrine carcinoma are gastrointestinal tract and its accessory glands, and lungs. Materials and Methods: One-hundred fifty cases diagnosed with metastatic brain lesions were retrieved from hospital records within 5 years. For these cases, the primary neoplasm, histopathological classification, metastasis, treatment, and fate all were studied. Results: Intracranial deposits were detected in 10%. The primary lesion was in the lungs in 87% of patients, and 1 patient in the breast and 1 in esophagus. Pathological classification of the primary lesion was Grade 2 (MIB-1: 3–20%) in 1 patient and neuroendocrine carcinoma (MIB-1: ≥21%) in 14 patients. The median period from onset of the primary lesion up to diagnosis of brain metastasis was 12.8 months. About 33% of patients had a single metastasis whereas 67% patients had multiple metastases. Brain metastasis was extirpated in 33% of patients. Stereotactic radiotherapy alone was administered in 20% of patients, and brain metastasis was favorably controlled in most of the patients with coadministration of cranial irradiation as appropriate. The median survival period from diagnosis of brain metastasis was 8.1 months. Conclusion: Most of patients with brain metastasis from neuroendocrine carcinoma showed the primary lesion in the lungs, and they had multiple metastases to the liver, lymph nodes, bones, and so forth at the time of diagnosis of brain metastasis. The guidelines for accurate diagnosis and treatment of neuroendocrine carcinoma should be immediately established based on further analyses of those patients with brain metastasis.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1047    
    Printed12    
    Emailed0    
    PDF Downloaded31    
    Comments [Add]    

Recommend this journal