Journal of Neurosciences in Rural Practice
Year : 2015  |  Volume : 6  |  Issue : 3  |  Page : 326-330

To study the correlation of serum S-100 protein level with the severity of stroke and its prognostic implication

1 Department of Medicine, SP Medical College, PBM Hospital, Bikaner, Rajasthan, India
2 Department of Medicine, SN Medical College, Jodhpur, Rajasthan, India

Correspondence Address:
Harish Kumar
Department of Medicine, SP Medical College, PBM Hospital, Bikaner - 334 001, Rajasthan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-3147.158751

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Objective: This study investigated correlation between mortality, stroke subtype and stroke severity with serum S-100 protein level prior to the treatment of the patients admitted to the emergency department and diagnosed with a stroke. Methods: Pretreatment sample were collected from the patients (n = 142) to determine S-100 protein level, age and sex-matched healthy individuals (n = 40) served as control. All patients had cranial computerized tomography scan/magnetic resonance imaging in the first 24 h. The neurological evaluation was made with the National Institute of Health Stroke Scale (NIHSS) in the acute stage. Results: Compared with controls, S-100 protein level were significantly higher in the stroke groups. In stroke groups, S-100 protein level was more significantly higher in the ischemic group than hemorrhage and transient ischemic attack group and highest in expired patients. Conclusion: Serum S-100 protein measurement can be used as an early marker of brain damage. There is a role of S-100 protein as a co-predictor of outcome in patients with acute stroke.

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