Cytologic diagnosis of undifferentiated high grade pleomorphic sarcoma of breast presenting with brain metastasis

Indranil Chakrabarti; Nilanjana Ghosh; Amita Giri

doi:10.4103/0976-3147.112763

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Case Report

4 (

); 188-190

doi:

10.4103/0976-3147.112763

Cytologic diagnosis of undifferentiated high grade pleomorphic sarcoma of breast presenting with brain metastasis

Indranil Chakrabarti, Nilanjana Ghosh¹, Amita Giri

Departments of Pathology, North Bengal Medical College, Sushrutanagar, Darjeeling, West Bengal, India

1Departments of Community Medicine, North Bengal Medical College, Sushrutanagar, Darjeeling, West Bengal, India

Address for correspondence: Dr. Indranil Chakrabarti Department of Pathology, North Bengal Medical College Sushrutanagar, Darjeeling, West Bengal India drinch@rediffmail.com

Journal of Neurosciences in Rural Practice

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Abstract

ABSTRACT

Primary sarcoma of breast are rare. Diagnosis by aspiration cytology is difficult due to nonspecific cytomorphologic features. An initial presentation with neurological symptoms due to metastasis of breast sarcoma to the brain has not been previously reported. Here, we describe a case of a 60‑year-old female who presented with headache, dizziness and convulsion and was subsequently diagnosed with undifferentiated high grade pleomorphic sarcoma of breast with cerebellar metastasis.

Keywords

Aspiration cytology

breast sarcoma

cerebellar metastasis

pleomorphic malignant fibrous histiocytoma

undifferentiated high grade pleomorphic sarcoma

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Conflict of Interest

None declared

References

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[1] Jeong Y. J., Oh H. K., Bong J. G., . Undifferentiated pleomorphic sarcoma of the male breast causing diagnostic challenges. J Breast Cancer. 2011;14:241-6.
[Google Scholar]

[2] Fletcher C. D., Unni K. K., Mertens F, . World Health Organization Classification of Tumors: Pathology and Genetics of Tumors of Soft Tissue and Bone. Lyon: IARC Press; 2002. p. :9-154.
[Google Scholar]

[3] Chhieng D. C., Cangiarella J. F., Waisman J, Fernandez G, Cohen J. M., . Fine-needle aspiration cytology of spindle cell lesions of the breast. Cancer. 1999;87:359-71.
[Google Scholar]

[4] Silverman J. F., Geisinger K. R., Frable W. J., . Fine-needle aspiration cytology of mesenchymal tumors of the breast. Diagn Cytopathol. 1988;4:50-8.
[Google Scholar]

[5] Stanley M. W., Tani E. M., Horwitz C. A., Tulman S, Skoog L, . Primary spindle-cell sarcomas of the breast: Diagnosis by fine-needle aspiration. Diagn Cytopathol. 1988;4:244-9.
[Google Scholar]

[6] Sharma P, Jain S, Nigam S, Bahadur A. K., Ouseph M. M., . Malignant fibrous histiocytoma of the chest wall masquerading as medullary Breast carcinoma- A case report. Acta Cytol. 2006;50:577-80.
[Google Scholar]

[7] Fletcher C. D., . The evolving classification of soft tissue tumours: An update based on the new WHO classification. Histopathology. 2006;48:3-12.
[Google Scholar]

[8] Adem C, Reynolds C, Ingle J. N., Nascimento A. G., . Primary breast sarcoma: Clinicopathologic series from the Mayo clinic and review of the literature. Br J Cancer. 2004;91:237-41.
[Google Scholar]

[9] Hartel P. H., Bratthauer G, Hartel J. V., Fanburg-Smith J. C., . Primary malignant fibrous histiocytoma (myxofibrosarcoma/pleomorphic sarcoma not otherwise specified) of the breast: Clinicopathologic study of 19 cases. Ann Diagn Pathol. 2011;15:407-13.
[Google Scholar]

Cytologic diagnosis of undifferentiated high grade pleomorphic sarcoma of breast presenting with brain metastasis

Abstract

ABSTRACT

Keywords

Aspiration cytology

breast sarcoma

cerebellar metastasis

pleomorphic malignant fibrous histiocytoma

undifferentiated high grade pleomorphic sarcoma

Conflict of Interest

References

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