Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
Book Review
Brief Report
Case Letter
Case Report
Case Series
Commentary
Current Issue
Editorial
Erratum
Guest Editorial
Images
Images in Neurology
Images in Neuroscience
Images in Neurosciences
Letter to Editor
Letter to the Editor
Letters to Editor
Letters to the Editor
Media and News
None
Notice of Retraction
Obituary
Original Article
Point of View
Position Paper
Review Article
Short Communication
Systematic Review
Systematic Review Article
Technical Note
Techniques in Neurosurgery
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
Book Review
Brief Report
Case Letter
Case Report
Case Series
Commentary
Current Issue
Editorial
Erratum
Guest Editorial
Images
Images in Neurology
Images in Neuroscience
Images in Neurosciences
Letter to Editor
Letter to the Editor
Letters to Editor
Letters to the Editor
Media and News
None
Notice of Retraction
Obituary
Original Article
Point of View
Position Paper
Review Article
Short Communication
Systematic Review
Systematic Review Article
Technical Note
Techniques in Neurosurgery
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
Book Review
Brief Report
Case Letter
Case Report
Case Series
Commentary
Current Issue
Editorial
Erratum
Guest Editorial
Images
Images in Neurology
Images in Neuroscience
Images in Neurosciences
Letter to Editor
Letter to the Editor
Letters to Editor
Letters to the Editor
Media and News
None
Notice of Retraction
Obituary
Original Article
Point of View
Position Paper
Review Article
Short Communication
Systematic Review
Systematic Review Article
Technical Note
Techniques in Neurosurgery
View/Download PDF

Translate this page into:

Case Report
4 (
1
); 70-72
doi:
10.4103/0976-3147.105621

Generalized hyperpigmentation in Wilson’s disease: An unusual association

Departments of Pediatrics, Institute of Post Graduate Medical education and Research, Kolkata, India
North Bengal Medical College, West Bengal, India
Address for correspondence: Dr. Madhumita Nandi 6/6, Naren Sarkar Road, Barisha, Kolkata, West Bengal India madhumitabanik@rediffmail.com
Licence
This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
Disclaimer:
This article was originally published by Thieme Medical and Scientific Publishers Private Ltd. and was migrated to Scientific Scholar after the change of Publisher.

Abstract

ABSTRACT

Wilson’s disease, an autosomal recessive disorder of copper metabolism, most commonly presents either with hepatic or neurological features. But, it may sometimes have certain atypical presentations posing diagnostic difficulties. We report here a case of Wilson’s disease presenting with generalized hyperpigmentation of skin who also developed neurological manifestations subsequently. We aim to highlight the importance of keeping Wilson’s disease as one of the differentials in patients who present with hyperpigmentation and neurological symptoms compatible with copper deposits in the central nervous system and proceed for investigations accordingly.

Keywords

Copper toxicity
hyperpigmentation
Wilson’s disease

Conflicts of interest

None declared

REFERENCES

  1. , , , , . Clinical presentation, diagnosis and long-term outcome of Wilson’s disease: A cohort study. Gut. 2007;56:115-20.
    [Google Scholar]
  2. , , , . Wilson’s disease presenting as respiratory failure. Indian J Pediatr. 2006;73:99-100.
    [Google Scholar]
  3. , , , . Wilson’s disease. Indian J Pediatr. 2002;69:785-91.
    [Google Scholar]
  4. , , . Atypical presentation of Wilson’s disease. J Nepal Paediatr Soc. 2008;28:66-7.
    [Google Scholar]
  5. , , , , . Familial Wilson’s disease: Copper indued hemolysis, hypersplenism andhyperpigmentation as the main symptoms. Schweiz Med Wochenschr. 1975;105:872-9.
    [Google Scholar]
  6. , , , , , , et al. . Wilson disease in children: Analysis of 57 cases. J Pediatr Gastroenterol Nutr. 2009;48:72-7.
    [Google Scholar]
  7. , , , , , . Wilson’s disease: A study of 21 cases from North-West India. Ann Indian Acad Neurol. 2007;10:255-8.
    [Google Scholar]
  8. , , , , . Skin pigmentation in Wilson’s disease. JAMA. 1970;211:1542-3.
    [Google Scholar]
  9. , , , , , , . Wilson’s disease in southern Brazil: A 40-year follow-up study. Clinics (Sao Paulo). 2011;66:411-6.
    [Google Scholar]
  10. , . Wilson’s disease.Pediatric Gastroenterology and Hepatology. Hyderabad, New Delhi: Paras Medical Publisher; . p. :p. 551-68. In: editor
    [Google Scholar]

Fulltext Views
239

PDF downloads
192
View/Download PDF
Download Citations
BibTeX
RIS
Show Sections