Journal of Neurosciences in Rural Practice
 


 
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REVIEW ARTICLE
Year : 2011  |  Volume : 2  |  Issue : 1  |  Page : 56-61  

Effect of plant extracts on Alzheimer's disease: An insight into therapeutic avenues


1 Capital College, Garden City Group of Institutions, Bangalore, India
2 Srikrishnadevaraya University, Anantapur, India

Date of Web Publication28-Apr-2011

Correspondence Address:
M Obulesu
Department of Biotechnology, Rayalaseema University, Kurnool, Andhra Pradesh
India
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DOI: 10.4103/0976-3147.80102

PMID: 21716802

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   Abstract 

Alzheimer's disease (AD) is a devastative neurodegenerative disorder which needs adequate studies on effective treatment options. The extracts of plants and their effect on the amelioration of AD symptoms have been extensively studied. This paper summarizes the mechanisms like acetylcholinesterase (AChE) inhibition, modification of monoamines, antiamyloid aggregation effect, and antioxidant activity which are actively entailed in the process of amelioration of AD symptoms. These effects are induced by extracts of a few plants of different origin like Yizhi Jiannao, Moringa oleifera (Drumstick tree), Ginkgo Biloba (Ginkgo/Maidenhair tree), Cassia obtisufolia (Sicklepod), Desmodium gangeticum (Sal Leaved Desmodium), Melissa officinalis (Lemon Balm), and Salvia officinalis (Garden sage, common sage).

Keywords: Alzheimer′s disease, antiamyloid aggregation, antioxidants, acetyl choline esterase inhibitors, plant extracts.


How to cite this article:
Obulesu M, Rao DM. Effect of plant extracts on Alzheimer's disease: An insight into therapeutic avenues. J Neurosci Rural Pract 2011;2:56-61

How to cite this URL:
Obulesu M, Rao DM. Effect of plant extracts on Alzheimer's disease: An insight into therapeutic avenues. J Neurosci Rural Pract [serial online] 2011 [cited 2014 Sep 1];2:56-61. Available from: http://www.ruralneuropractice.com/text.asp?2011/2/1/56/80102


   Introduction Top


Alzheimer's association estimated that one in eight Americans above age of 65 years and half of the Americans above age of 85 years have been presently suffering from this devastative neurodegenerative disorder. [1] According to this estimation, the number of patients may reach 16 million by 2050 [1],[2],[3],[4] thus augmenting the economic cost of Alzheimer's disease (AD) health care system, which is 80-100 billion dollars presently. [1] Loss of cholinergic synapses in hippocampus and neocortex has been a consistent finding in AD, thus accentuating the need to employ a substantial strategy that regulates the AChE function to combat this defect. [1] Tacrine, donepezil, and rivastigmine are a few AChE inhibitors approved by U.S. Food and Drug Administration for the amelioration of AD symptoms. [1],[5],[6] Although advent of such inhibitors has been effective in function yet there has been augmenting need to quest for new drugs. [1] In the light of this fact, polyphenolic compounds from fruits and vegetables have been exploited because of their potential antioxidative properties. [1],[7],[8],[9],[10],[11],[12] There has been growing focus on traditional herbal medicines presently since the failure of existing treatments. [13] The first neurotransmitter found to be involved in AD is acetylcholine. [14] Therefore, there have been manifold studies to employ AChE inhibitors.

Plants provide wealth of bioactive compounds, which exert a substantial strategy for the treatment of neurological disorders such as Alzheimer's disease. [15] It has been recently shown that a Chinese herb, Yizhi Jiannao Granules is effective in improving AD symptoms, and it also aggravates such amelioration when combined with acupuncture. [16] Zeatin has been found to have a protective role against Aβ-induced neurotoxicity in PC12 cells and ameliorate scopolamine-induced amnesia in ICR mice.[17]


   Cholinesterase Inhibition Top


Growing lines of evidence suggests that among 73 native and naturalized plants collected from the central region of Argentina, organic fractions obtained from extracts of Achyrocline tomentosa (Marcela) (Asteraceae), Eupatorium viscidum (Common boneset) (Asteraceae), Ruprechtia apetala (manzano del campo) (Polygonaceae), Trichocline reptans (arnica) (Asteraceae), and Zanthoxylum coco (cochucho, coco) (Rutaceae) demonstrated substantial inhibition of AChE (higher than 80%)[Table 1]. [15] Poncirus trifoliate (Trifoliate Orange) extract has been shown to inhibit AchE considerably. [1] Methoxsalen isolated from medicinal herbs Treculia obovoidea (Catterall) and Angelica archangelica (Garden Angelica), shows antimicrobial and anti-AchE activities in vitro. [1],[18],[19],[20]
Table 1: Neuroprotective mechanisms exerted by various plant extracts

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Studies on the seeds of Cassia obtisufolia proved their neuroprotective role in mice via attenuation of secondary Ca 2+ dysregulation and mitochondrial toxin 3-NP. [13] Moreover, they can improve memory impairment via AChE inhibition. [13],[21] Flavonoids, a group of phenolic compounds which demonstrate antimutagenic, anticarcinogenic, and antiageing properties [22],[23],[24],[25] may be responsible for neuroprotective role of Cassia obtusifolia extracts. [13] Dried ginger has been shown to induce Ca 2+ antagonistic activity and butylcholinesterase inhibitory activity which are effective in AD treatment. [26]


   Modification of Monoamines Top


Moringa oleifera (MO) which belongs to the family Moringaceae, is prevalent almost all over the Asian and African countries. Its fruit and leaves which show anti-inflammatory and hypotensive effect are consumed as food by the people. [27],[28],[29] It has been found recently that Moringa oleifera leaf extract which is not toxic even at higher concentration levels, enhances memory via nootropics activity and provides substantial antioxidants like vitamin C and E to combat oxidative stress in AD. [27],[30],[31],[32] Wealth of studies substantiated that monoamines entailed in the memory loss are altered by Moringa oleifera leaf extracts [Table 1]. [27],[33] Several lines of evidence also suggest that colchicines-induced AD can be ameliorated by ethanolic extract of Moringa oleifera by modifying the brain monoamines (norepinephrine, dopamine, and serotonin) and electrical activity in a rat model. [27]


   Antiamyloid Aggregation Effect Top


Ginkgo biloba being a potential store house of antioxidants offers ample of health benefits to AD patients like antiamyloid aggregation effect [Table 1]. [34],[35],[36] Extensive studies on Ginkgo biloba revealed that 240 mg of Ginkgo biloba per day can decrease the incidence of AD. [34] Although there are a few substantial studies on Ginkgo biloba to ameliorate AD symptoms and worldwide sales of it exceed $249 million annually in the United States, [34] yet there has been augmenting need to initiate more promising clinical trials in this direction. [34] It has been found that the Ginkgo biloba extracts ameliorate cognitive defects in a mouse model of AD (Tg2576). [37],[38] Manifold clinical trials proved amelioration of AD symptoms [39],[40] and the clinical evaluation of EGb 761 that is widely used for dementia in many countries and an extensively used dietary supplement in the United States for memory enhancement, [41],[42],[4]3,[44] is presently in progress. [45] Although in vivo mechanism for EGb 761 is elusive yet it has been found to ameliorate AD symptoms both in vivo (AD mice Tg 2576) [46] and in vitro. [36],[37],[47],[48],[49],[50],[51] Upregulation of a small APP release, a nontoxic, nonamyloidogenic metabolite of APP, via a PKC-independent manner in hippocampi and cortices of EGb761-treated rats has been studied. [37],[52]


   Antioxidants Top


Desmodium gangeticum generally known as Salparni, is prevalent in India and has significant medicinal use as a bitter tonic, febrifuge, digestive, anticatarrhal, antiemetic, [53],[54] and anti-inflammatory conditions. [53],[55] Moreover, it has been extensively used in ayurveda for the amelioration of neurological symptoms. [53] Its extracts employed in mice to evaluate the efficacy in amelioration of AD symptoms via nootropic activity and deterioration of AChE activity yielded considerable outcome. [53] It also possesses antioxidative property [Table 1]. [53],[56]

Rosmarinic acid isolated from Salvia officinalis, attenuates a number of events provoked by Aβ-like reactive oxygen species formation, lipid peroxidation, DNA fragmentation, caspase-3 activation, and tau protein hyperphosphorylation. [57],[58] Despite a few pharmacological activities of sage attributed [59] to AD include antioxidant activity, [60] anti-inflammatory effects [61] and cholinesterase inhibition, [62] yet the mode of sage-protective action is unclear. [57] Rosmarinic acid has been known to initiate antioxidant, anti-inflammatory, antimutagen, antibacterial, and antiviral properties. [63] Rosmarinic acid effectively inhibits hall mark events of AD-like formation of fibrils from Aβ, destabilization preformed Aβ fibrils in vitro and tau hyperphosphorylation. [57],[64]


   Neuroprotective Effect of Traditional Japanese-Chinese, Korean, and European Plant Extracts Top


Kihi-to, a traditional Japanese-Chinese traditional medicine, shows significant amelioration of Aβ(25-35)-induced impairments in memory acquisition, memory retention, and object recognition memory in mice. It also attenuates neuritic, synaptic, and myelin losses in the cerebral cortex, hippocampus and striatum. Kihi-to also effectively attenuates the calpain augmentation in the cerebral cortex and hippocampus. [65] Abundance of research revealed that among several traditional Chinese medicines, Ginseng Radix [66],[67] Astragali Radix [68] and Polygalae Radix [69] demonstrated potential axonal extension activity against amyloid β (Aβ) (25-35)-induced axonal atrophy. [65]

Among the 90 traditional Korean tea plants, methanolic extracts of Pueraria thunbergiana (Kudzu) rich in Daidzein (4,7 dihydroxy isoflavone), are actively entailed in the amelioration of scopolamine induced amnesia in mice. [70] Abundance of research unraveled the neuroprotective effect of Gossypium Herbaceam extracts against ibotenic acid induced learning and memory impairment in rats. [71]

Melissa officinalis extract has been proven to ameliorate mild to moderate AD. [14] Among the European herbs M. officinalis and another herb in the labiatae family, S. officinalis, might present a natural treatment for AD by amelioration of cognition. [14],[58],[72] This herb actively amends mood and cognitive ability during acute administration in healthy young volunteers and has no side effects or symptoms of toxicity. [14],[73],[74],[75] S. triloba (Greek Sage) and Teucrium polium (Cat Thyme) are also effective in amelioration of AD symptoms. [76]


   Ayurvedic Plants and AD Top


Formulation of some Indian medicinal plants classified in Ayurveda, the classic Indian system of medicine, as Medhyarasayanas or drugs considerably ameliorates memory and intellect. [77],[78] Studies on rats demonstrated that the oral administration of Trasina, a herbal formulation, once daily for 21 days can effectively ameliorate colchicine induced effects like reduced frontal, cortical and hippocampal acetylcholine (Ach) concentrations, choline acetyltransferase (ChAT) activity, and muscarinic cholinergic receptor (MCR) binding. [77] It has been reported recently that alcoholic extract of Bacopa monnieri (Water Hyssop) significantly improves escape latency time in Morris water maze test and ameliorates reduction of neurons and cholinergic neuron densities in Wistar rats which are employed as AD animal models. [79] Anwala churna (Emblica officinalis Gaertn.), an Ayurvedic preparation showed an exemplary improvement in memory and brain cholinesterase activity, thus ameliorating the scopolamine induced amnesia in young and aged mice. [80]


   Curcumin Top


Curcuma longa (Turmeric) has been the source of Curcumin (diferuloylmethane), an orange-yellow component of turmeric or curry powder. This being a potential polyphenol natural product has been predominantly used in some medicinal preparation or used as a food-coloring agent. Wealth of studies in vitro and in vivo substantiated that curcumin has anticancer, antiviral, antiarthritic, anti-amyloid, antioxidant, and anti-inflammatory properties. The molecular underpinnings of these effects have been found to involve the regulation of diverse molecular targets, including transcription factors (such as nuclear factor-κB), growth factors (such as vascular endothelial cell growth factor), inflammatory cytokines (such as tumor necrosis factor, interleukin 1 and interleukin 6), protein kinases (such as mammalian target of rapamycin, mitogen-activated protein kinases, and Akt) and other enzymes (such as cyclooxygenase 2 and 5 lipoxygenase). Its ability to regulate multiple targets and its safety for human use, made curcumin an amenable therapeutic agent for the prevention and/or treatment of various malignant diseases, arthritis, allergies, AD, and other inflammatory illnesses. [81]

Recent studies on cultured astrocytes obtained from pregnant Sprague-Dawley (SD) rat and neonatal 0-2-day-old SD rats showed improved neuronal survival by curcumin treatment in NMDA toxicity through the activation of PI3K/MAPK signaling pathways. [82] Studies employing surface plasmon resonance experiments, unraveled that the liposomes exposing the curcumin derivative (maintaining the planarity) demonstrate considerable affinity for Aβ1-42 fibrils (1-5 nM), through the exhibition of multivalent interactions, thus opening an amenable therapeutic avenue unlike the nonplanar curcumin. [83]


   Conclusion Top


There have been manifold studies to combat this dreadful neurodegenerative disorder for a few decades. Although a few drugs are available today for the management of AD and many plants and their extracts are extensively employed in animal studies and AD patients, yet no substantial drug or plant extract is able to reverse the AD symptoms adequately. The intervention of phytotherapy, which entails the use of herbal medicines may be a potential corner stone based on which treatment strategies can be streamlined. [14],[84],[85],[86] It is tangible that there has been augmenting need for such therapeutic intervention.

 
   References Top

1.Kim JK, Bae H, Kim MJ, Choi SJ, Cho HY, Hwang HJ, et al. Inhibitory effect of poncirus trifoliate on acetyl cholinesterase and attenuating activity against trimethyltin induced learning and memory impairment. Biosci Biotechnol Biochem 2009;73:1105-12.  Back to cited text no. 1
    
2.Heo HJ, Kim MJ, Lee JM, Choi SJ, Cho HY, Hong BS, et al. Naringenin from Citrus junos has an inhibitory effect on acetylcholinesterase and a mitigating effect on amnesia. Dement. Geriatr. Cogn Disord 2004;17:151-7.  Back to cited text no. 2
    
3.Prasad KN, Hovland AR, Cole WC, Prasad KC, Nahreini P, Edwards-Prasad J, et al. Multiple antioxidants in the prevention and treatment of Alzheimer disease: Analysis of biologic rationale. Clin Neuropharmacol 2000;23:2-13.  Back to cited text no. 3
    
4.Terry RD, Masliah E. Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment. Ann Neurol 1991;30:572-80.  Back to cited text no. 4
    
5.Candy JW, Perry RH, Perry EK, Irving D, Blessed G, Fairbairn AF. Pathological changes in the nucleus of Meynert in Alzheimer's and Parkinson's diseases. J Neurol Sci 1983;59:277-89.  Back to cited text no. 5
    
6.Loizzo MR, Tundis R, Menichini F, Menichini F. Natural products and their derivatives as cholinesterase inhibitors in the treatment of neurodegenerative disorders: An update. Curr Med Chem 2008;12:1209-28.   Back to cited text no. 6
    
7.Ak T, Gulcin I. Antioxidant and radical scavenging properties of curcumin. Chem Biol Interact 2008;174:27-37.   Back to cited text no. 7
    
8.Gulcin I. Antioxidant activity of caffeic acid (3,4-dihydroxycinnamic acid). Toxicology 2006;217:213-20.  Back to cited text no. 8
    
9.Burda S, Oleszek W. Antioxidant and antiradical activities of flavonoids. J Agric Food Chem 2001;49:2774-9.  Back to cited text no. 9
    
10.Cardenas M, Marder M, Blank VC, Roguin LP. Antitumor activity of some natural flavonoids and synthetic derivatives on various human and murine cancer cell lines. Bioorg Med Chem 2006;14:2966-71.  Back to cited text no. 10
    
11.Li N, Liu JH, Zhang J, Yu BY. Comparative evaluation of cytotoxicity and antioxidative activity of 20 flavonoids. J Agric Food Chem 2008;56:3876-83.  Back to cited text no. 11
    
12.Kris-Etherton PM, Hecker KD, Bonanome A, Coval SM, Binkoski AE, Hilpert KF, et al. Bioactive compounds in foods: Their role in the prevention of cardiovascular disease and cancer. Am J Med 2002;113:71S-88S.  Back to cited text no. 12
    
13.Drever BD, Anderson WG, Riedel, G, Kim DH, Ryu JH, Choi DY, et al. The seed extract of cassia obtusifolia offers neuroprotection to mouse hippocampal cultures. J Pharmacol Sci 2008;107:380-92.  Back to cited text no. 13
    
14.Akhondzadeh S, Noroozian M, Mohammadi M, Ohadinia S, Jamshidi AH, Khani M. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: A double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6.  Back to cited text no. 14
    
15.Carpinella MC, Andrione DG, Ruiz G, Palacios SM. Screening for acetylcholinesterase inhibitory activity in plant extracts from Argentina. Phytother Res 2009;24:259-63.  Back to cited text no. 15
    
16.Peng XW, Dong KL. Clinical observation on acupuncture combined with Yizhi Jiannao granules for treatment of Alzheimer's disease. Zhongguo Zhen Jiu 2009;29:269-71.  Back to cited text no. 16
    
17.Choi SJ, Jeong CH, Choi SG, Chun JY, Kim YJ, Lee J, et al. Zeatin prevents amyloid beta-induced neurotoxicity and scopolamine-induced cognitive deficits. J Med Food 2009;12:271-7.  Back to cited text no. 17
    
18.Kuete V, Ngameni B, Simo CC, Tankeu RK, Ngadjui BT, Meyer JJ, et al. Antimicrobial activity of the crude extracts and compounds from Ficus chlamydocarpa and Ficus cordata (Moraceae). J Ethnopharmacol 2008;120:17-24.  Back to cited text no. 18
    
19.Sigurdsson S, Gudbjarnason S. Antimicrobial activity of the crude extracts and compounds from Ficus chlamydocarpa and Ficus cordata (Moraceae). Z Naturforsch C 2007;62:689-93.  Back to cited text no. 19
    
20.Yu J, Wang L, Walzem RL, Miller EG, Pike LM, Patil BS. Antioxidant activity of citrus limonoids, flavonoids, and coumarins. J Agric Food Chem 2005;53:2009-14.   Back to cited text no. 20
    
21.Kim DH, Yoon BH, Kim YM, Lee S, Shin BY, Jung JW, et al. The seed extract of cassia obtusifolia ameliorates learning and memory impairments induced by scopolamine or transient cerebral hypoperfusion in mice. J Pharmacol Sci 2007;105:82-93.  Back to cited text no. 21
    
22.Bahorun T, Gressier B, Trotin F, Brunet C, Dine T, Luyckx M, et al. Oxygen species scavenging activity of phenolic extracts from hawthorn fresh plant organs and pharmaceutical preparations. Arzneimittelforschung 1996;46:1086-9.  Back to cited text no. 22
    
23.Bahorun T, Aumjaud E, Ramphul H, Rycha M, Luximon-Ramma A, Trotin F, et al. Phenolic constituents and antioxidant capacities of crataegus monogyna (hawthorn) callus extracts. Nahrung 2003;47:191-8.  Back to cited text no. 23
    
24.Lien EJ, Ren S, Bui HH, Wang R. Quantitative structure-activity relationship analysis of phenolic antioxidants. Free Radic Biol Med 1999;26:285-94.  Back to cited text no. 24
    
25.Luximon-Ramma A, Bahorun T, Soobrattee MA, Aruoma OI. Antioxidant activities of phenolic, proanthocyanidin, and flavonoid components in extracts of cassia fistula. J Agric Food Chem 2002;50:5042-7.  Back to cited text no. 25
    
26.Ghayur MN, Gilani AH, Ahmed T, Khalid A, Nawaz SA, Agbedahunsi JM, et al. Muscarinic, Ca(++) antagonist and specific butyrylcholinesterase inhibitory activity of dried ginger extract might explain its use in dementia. J Pharm Pharmacol 2008;60:1375-83.  Back to cited text no. 26
    
27.Ganguly R, Guha D. Alteration of brain monoamines and EEG wave pattern in rat model of Alzheimer's disease and protection by Moringa oleifera. Indian J Med Res 2008;128:744-51.  Back to cited text no. 27
    
28.Faizi S, Siddiqui BS, Saleem R, Siddiqui S, Aftab K, Gilani AH. Fully acetylated carbamates and hypotensive thiocarbamate glycosides from Moringa oleifera. Phytochemistry 1995;38:957-63.  Back to cited text no. 28
    
29.Caceres A, Saravia A, Rizzo S, Zabala L, Leon ED, Nave F. Pharmacological properties of Moringa oleifera. 2: Screening for antispasmodic, anti-inflammatoryand diuretic activity. J Ethnopharmacol 1992;36:233-7.  Back to cited text no. 29
    
30.Majumdar K, Gupta M, Chakrobarty S, Pal DK. Evaluation of hematological and hepatorenal functions of methanolic extract of Moringa oleifera Lam. root treated mice. Indian J Exp Biol 1999;37:612-4.  Back to cited text no. 30
    
31.Mohan M, Kaul N, Punekar A, Girnar R, Junnare P, Patil L. Nootropic activity of Moringa oleifera leaves. J Nat Remedies 2005;5:59-62.  Back to cited text no. 31
    
32.Ganguly R, Hazra R, Ray K, Guha D. Effect of Moringa oleifera in experimental model of Alzheimer's disease: Role of antioxidants. Ann Neurosci 2005;12:36-9.  Back to cited text no. 32
    
33.Ganguly R, Guha D. Protective role of an Indian herb, Moringa oleifera in memory impairment by high altitude hypoxic exposure: Possible role of monoamines. Biogenic Amines 2006;20:121-33.  Back to cited text no. 33
    
34.DeKosky ST, Williamson JD, Fitzpatrick AL, Kronmal RA, Ives DG, Saxton JA, et al. Ginkgo biloba for prevention of dementia a randomized controlled trial. JAMA 2008;300:2253-62.  Back to cited text no. 34
    
35.Pietri S, Maurelli E, Drieu K, Culcasi M. Cardioprotective and anti-oxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761). J Mol Cell Cardiol 1997;29:733-42.  Back to cited text no. 35
    
36.Luo Y, Smith JV, Paramasivam V, Burdick A, Curry KJ, Buford JP, et al. Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761. Proc Natl Acad Sci USA 2002;99:12197-202.  Back to cited text no. 36
    
37.Tchantchou F, Xu Y, Wu Y, Christen Y, Luo Y. EGb 761 enhances adult hippocampal neurogenesis and phosphorylation of CREB in transgenic mouse model of Alzheimer's disease. FASEB J 2007;21:2400-8.  Back to cited text no. 37
    
38.Augustin S, Rimbach G, Augustin K, Schliebs R, Wolffram S, Cermak R. Effect of a short- and long-term treatment with Ginkgo biloba extract on amyloid precursor protein levels in a transgenic mouse model relevant to Alzheimer's disease. Arch Biochem Biophys 2009;481:177-82.   Back to cited text no. 38
    
39.DeFeudis FV, Drieu K. Ginkgo biloba extract (EGb 761) and CNS functions: basic studies and clinical applications. Curr Drug Targets 2000;1:25-58.   Back to cited text no. 39
    
40.Smith JV, Luo Y. Studies on molecular mechanisms of Ginkgo biloba extract. Appl Microbiol Biotechnol 2004;64:465-72.  Back to cited text no. 40
    
41.Le Bars PL, Katz MM, Berman N, Itil TM, Freedman AM, Schatzberg AF. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia: North American EGb Study Group. J Am Med Assoc 1997;278:1327-32.  Back to cited text no. 41
    
42.Oken BS, Storzzbach DM, Kaye JA. The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease. Arch Neurol 1998;55:1409-15.   Back to cited text no. 42
    
43.Mix JA, David Crews W Jr. A double-blind, placebo-controlled, randomized trial of Ginkgo biloba extract EGb 761(R) in a sample of cognitively intact older adults: Neuropsychological findings. Hum Psychopharmacol 2002;17:267-77.  Back to cited text no. 43
    
44.Mazza M, Capuano A, Bria P, Mazza S. Ginkgo biloba and donepezil: A comparison in the treatment of Alzheimer's dementia in a randomized placebo-controlled doubleblind study. Eur J Neurol 2006;13:981-5.  Back to cited text no. 44
    
45.DeKosky ST, Fitzpatrick A, Ives DG, Saxton J, Williamson J, Lopez OL, et al. The Ginkgo Evaluation of Memory (GEM) study: Design and baseline data of a randomized trial of Ginkgo biloba extract in prevention of dementia. Contemp Clin Trials 2006;27:238-53.  Back to cited text no. 45
    
46.Stackman RW, Eckenstein F, Frei B, Kulhanek D, Nowlin J, Quinn JF. Prevention of age-related spatial memory deficits in a transgenic mouse model of Alzheimer's disease by chronic Ginkgo biloba treatment. Exp Neurol 2003;184:510-20.  Back to cited text no. 46
    
47.Bastianetto S, Zheng WH, Quirion R. The Ginkgo biloba extract (EGb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: Involvement of its flavonoid constituents and protein kinase C. J Neurochem 2000;74:2268-77.  Back to cited text no. 47
    
48.Yao Z, Drieu K, Papadopoulos V. The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from beta-amyloid-induced cell death by inhibiting the formation of beta-amyloid-derived diffusible neurotoxic ligands. Brain Res 2001;889:181-90.  Back to cited text no. 48
    
49.Gohil K, Packer L. Bioflavonoid-rich botanical extracts show antioxidant and gene regulatory activity. Ann N Y Acad Sci 2002;957:70-7.  Back to cited text no. 49
    
50.Smith JV, Burdick AJ, Golik P, Khan I, Wallace D, Luo Y. Anti-apoptotic properties of Ginkgo biloba extract EGb 761 in differentiated PC12 cells. Cell Mol Biol (Noisy-le-grand) 2002;48:699-707.  Back to cited text no. 50
    
51.Spencer JP, Rice-Evans C, Williams RJ. Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability. J Biol Chem 2003;278:34783-93.  Back to cited text no. 51
    
52.Colciaghi F, Borroni B, Zimmermann M, Bellone C, Longhi A, Padovani A, et al. Amyloid precursor protein metabolism is regulated toward alpha-secretase pathway by Ginkgo biloba extracts. Neurobiol Dis 2004;16:454-60.  Back to cited text no. 52
    
53.Joshi H, Parle M. Antiamnestic effects of Demodium gangeticum in mice. Yakugaku Zasshi 2006;126:795-804.  Back to cited text no. 53
    
54.Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants. New Delhi: Council of Scientific and Industrial Research; 1956.  Back to cited text no. 54
    
55.Purushothaman KK, Chandrasekharan S, Balakrishna K, Connolly JD. Gangetinin and desmodin, two minor pterocarpanoids of Desmodium gangeticum. Phytochemistry 1975;14:1129-30.  Back to cited text no. 55
    
56.Govindarajan R, Rastogi S, Vijayakumar M, Shirwaikar A, Rawat AK, Mehrotra S, et al. Studies on the antioxidant activities of Desmodium gangeticum. Biol Pharm Bull 2003;26:1424-7.  Back to cited text no. 56
    
57.Iuvone T, De Filippis D, Esposito G, D'Amico A, Izzo AA. The spice sage and its active ingredient rosmarinic acid protect PC12 Cells from amyloid: Peptide-induced neurotoxicity. J Pharmacol Exp Ther 2006;317:1143-9.   Back to cited text no. 57
    
58.Perry EK, Pickering AT, Wang WW, Houghton PJ, Perry NS. Medicinal plants and Alzheimer's disease: From ethnobotany to phytotherapy. J Pharm. Pharmacol 1999;51:527-34.  Back to cited text no. 58
    
59.Howes MJ, Perry NS, Houghton PJ. Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders. Phytother Res 2003;17:1-18.  Back to cited text no. 59
    
60.Hohmann J, Zupko I, Redei D, Csanyi M, Falkay G, Mathe I, et al. Protective effects of the aerial parts of Salvia officinalis, Melissa officinalis and Lavandula angustifolia and their constituents against enzyme-dependent and enzyme-independent lipid peroxidation. Planta Med 1999;65:576-8.  Back to cited text no. 60
    
61.Baricevic D, Sosa S, Della Loggia R, Tubaro A, Simonovska B, Krasna A, et al. Topical anti-inflammatory activity of Salvia officinalis L. leaves: The relevance of ursolic acid. J Ethnopharmacol 2001;75:125-32.   Back to cited text no. 61
    
62.Perry N, Court G, Bidet N, Court J, Perry E. European herbs with cholinergic activities: potential in dementia therapy. Int J Geriatr Psychiatry 1996;11:1063-9.  Back to cited text no. 62
    
63.Petersen M, Simmonds MS. Rosmarinic acid. Phytochemistry 2003;62:121-5.  Back to cited text no. 63
    
64.Ono K, Hasegawa K, Naiki H, Yamada M. Curcumin has potent antiamyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro. J Neurosci Res 2004;15:742-50.  Back to cited text no. 64
    
65.Tohda C, Naito R, Joyashiki E. Kihi-to, a herbal traditional medicine, improves A beta (25-35)-induced memory impairment and losses of neuritis and synapses. BMC Compl Alternat Med 2008;8:49.  Back to cited text no. 65
    
66.Tohda C, Matsumoto N, Zou K, Meselhy MR, Komatsu K. Axonal and dendritic extension by protopanaxadiol-type saponins from ginseng drugs in SK-N-SH cells. Jpn J Pharmacol 2002;90:254-62.  Back to cited text no. 66
    
67.Tohda C, Matsumoto N, Zou K, Meselhy MR, Komatsu K. Aβ(25-35)-induced memory impairment, axonal atrophy, and synaptic loss are ameliorated by M1, A metabolite of protopanaxadiol- type saponins. Neuropsychopharmacology 2004;29:860-8.  Back to cited text no. 67
    
68.Tohda C, Tamura T, Matsuyama S, Komatsu K. Promotion of axonal maturation and prevention of memory loss in mice by extracts of Astragalus mongholicus. Br J Pharmacol 2006;149:532-41.  Back to cited text no. 68
    
69.Naito R, Tohda C. Characterization of anti-neurodegenerative effects of Polygala tenuifolia in Aβ(25-35)-treated cortical neurons. Biol Pharm Bull 2006;29:1892-6.  Back to cited text no. 69
    
70.Heo HJ, Suh YM, Kim MJ, Choi SJ, Mun NS, Kim HK, et al. Daidzein activates choline acetyltransferase from mc-IXC cells and improves drug-induced amnesia. Biosci Biotechnol Biochem 2006;70:107-11.   Back to cited text no. 70
    
71.Ji C, Li Q, Aisa H, Yang N, Dong YL, Liu YY, et al. Gossypium herbaceam extracts attenuate ibotenic acid-induced excitotoxicity in rat hippocampus. J Alzheimers Dis 2009;16:331-9.  Back to cited text no. 71
    
72.Perry EK, Pikering AT, Wang WW, Houghton P, Perry NS. Medicinal plants and Alzheimer's disease: Integrating ethnobotanical and contemporary scientific evidence. J Altern Complement Med 1998;4:419-28.  Back to cited text no. 72
    
73.Schhultz V, Hansel R, Tyler V. Rational phytotherapy: A physician's guide to herbal medicine. New York: Springer-Verlag; 1998.  Back to cited text no. 73
    
74.Wake G, Court J, Pikering A, Lewis R, Wilkins R, Perry E. CNS acetylcholine receptor activity in European medicinal plants traditionally used to improve failing memory. J Ethnopharmacol 2000;69:105-14.  Back to cited text no. 74
    
75.Kennedy DO, Scholey AB, Tildesley NT, Perry EK, Wesnes KA. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953-64.  Back to cited text no. 75
    
76.Orhan I, Aslan M. Appraisal of scopolamine-induced antiamnesic effect in mice and in vitro antiacetylcholinesterase and antioxidant activities of some traditionally used Lamiaceae plants. J Ethnopharmacol 2009;122:327-32.  Back to cited text no. 76
    
77.Bhattacharya SK, Kumar A. Effect of Trasina, an ayurvedic herbal formulation, on experimental models of Alzheimer's disease and central cholinergic markers in rats. J Altern Complement Med 1997;3:327-36.  Back to cited text no. 77
    
78.Kumar V. Potential medicinal plants for CNS disorders: An overview. Phytother Res 2006;20:1023-35.  Back to cited text no. 78
    
79.Uabundit N, Wattanathorn J, Mucimapura S, Ingkaninan K. Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer's disease model. J Ethnopharmacol 2010;127:26-31.  Back to cited text no. 79
    
80.Vasudevan M, Parle M. Memory enhancing activity of Anwala churna (Emblica officinalis Gaertn.): An Ayurvedic preparation. Physiol Behav 2007;91:46-54.   Back to cited text no. 80
    
81.Zhou H, Beevers CS, Huang S. The targets of curcumin. Curr Drug Targets 2011;12:332-47.  Back to cited text no. 81
    
82.Lin MS, Hung KS, Chiu WT, Sun YY, Tsai SH, Lin JW, et al. Curcumin enhances neuronal survival in N-methyl-D-aspartic acid toxicity by inducing RANTES expression in astrocytes via PI-3K and MAPK signaling pathways. Prog Neuropsychopharmacol Biol Psychiatry 2011.  Back to cited text no. 82
    
83.Mourtas S, Canovi M, Zona C, Aurilia D, Niarakis A, La Ferla B, et al. Curcumin-decorated nanoliposomes with very high affinity for amyloid-β1-42 peptide. Biomaterials 2011;32:1635-45.  Back to cited text no. 83
    
84.Akhondzadeh S, Noroozian M. Alzheimer's disease: Pathophysiology and pharmacotherapy. I Drugs 2002;4:1167-72.  Back to cited text no. 84
    
85.Bullock R. New drugs for Alzheimer's disease and other dementias. Br J Psychiatry 2002;180:135-9.  Back to cited text no. 85
    
86.Bullock R. Drug treatment in dementia. Curr Opin Psychiatry 2001;14:349-53.  Back to cited text no. 86
    



 
 
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    Abstract
    Introduction
    Cholinesterase I...
    Modification of ...
    Antiamyloid Aggr...
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